5-chloro-7-[(1-methylethyl)amino]pyrazolo[1,5-a]pyrimidine-3-carbonitrile

This compound is a synthetic small molecule belonging to the class of pyrazolo[1,5-a]pyrimidines. It features a chloro group at position 5 and an isopropylamino substituent at position 7 on the core heterocycle. The molecule has been studied as an ATP-binding site inhibitor targeting cyclin-dependent kinase 2 (CDK2), a key regulator of cell cycle progression. There are no approved indications or clinical trials in advanced phases for this compound; it remains experimental and has not reached clinical development beyond preclinical or early research stages. Its primary mechanism involves inhibition of CDK2 activity by binding to its ATP pocket, potentially interfering with cell proliferation pathways relevant in oncology research.[1][9]

Other names

5-chloro-7-(isopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile5-chloro-7-(propan-2-ylamino)-1H-pyrazolo[1,5-a]pyrimidin-8(7H)-onepyrazolo[1,5-a]pyrimidine derivative